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Why I Take Modafinil

At one time I had two different sleeping disorders but for whatever reason my trouble sleeping at night (insomnia) went away so now I focus mainly on staying awake during the day (excessive daytime sleepiness).

It’s tough sometimes.

Types of Sleeping Disorders

  • Narcolepsy
  • Hypersomnia
  • Excessive Daytime Sleepiness
  • Shift Work Sleep Disorder

The definitions for each of these sleeping disorders is in one of the other posts in my blog but suffice to say the first two disorders are pretty sever and the second two are not as drastic but these conditions still stem from an area of the brain that is misfiring.

I Suffer From Excessive Daytime Sleepiness

http://buyprovigil.modafinilonline.infoI am not a narcoleptic, so for the longest time I thought my excessive daytime sleepiness was just “collateral damage” from an addiction to methamphetamine I battled with in my 20′s that caused me no end of grief .

I’ve been clean for going on 10 years now so you can imagine how cautious I needed to be when I start talking about taking a pill that ‘wakes me up’.

I read about Provigil (Modafinil online) and excessive daytime sleepiness in the Readers Digest when I was a radiology student back in ’04.

It got my attention quick because I was on my way to falling asleep on my feet at the time.

You can only drink so much Mt. Dew.

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I Did A Lot Of Research On This Drug, Modafinil (Provigil)

I knew I needed a stimulant to treat my excessive daytime sleepiness but I couldn’t take anything that gave me a buzz or was habit forming.

I also could not take anything that would cause me to fail a urine test.

I wasn’t concerned about law enforcement anymore but you have to submit to a urinalysis to get hired for the job I was training for.

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Modafinil, Modapro, Modalert, Alertec and Online Pharmacy Sites

I found out real quick how many different names Modafinil gets sold under and how many different online pharmacy sites sell them.

There are quite a few.

Let me be very clear here…

THEY ARE NOT ALL THE SAME!

A site called Pills For Stress has a disclaimer that says:

each brand is produced differently, in different places and may look different but the only difference is cosmetic

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WRONG!

Every one is different.

I’ve tried most of them.

Most of them helped me with my excessive daytime sleepiness, but some didn’t.

I’ll go into more detail about what I know about these manufactures; Sun Pharma, Cipla and Cephalon, in another post.





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Obstructive Sleep Apnea

A good reason to buy Provigil online is because Provigil is a well known drug used in the treatment of several sleeping disorders, one of which is the condition known as obstructive sleep apnea.

In simple terms obstructive sleep apnea is a condition affecting the ability of a person to breathe, in which the throat narrows or closes during sleep.

This prevents an adequate supply of air from reaching the lungs, thereby lowering oxygen levels in the blood.

The low oxygen levels in the blood then cause the brain to activate a self-preservation mechanism to wake up the OSA sufferer.

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The Effects of Obstructive Sleep Apnea

The above description of obstructive sleep apnea does need some further explanation as to why a safe drug like Provigil might be required to treat the condition.

The problem is that an effect of the respiratory system becoming blocked by this condition is that, prior to the brain waking up the sufferer – breathing can cease.

While a physician wouldn’t be too concerned if the cessation of breathing lasted less than 10 seconds, anything more could have serious consequences – hence the prescription of a sleeping disorder drug like Provigil.

Another factor is the frequency of the episodes of cessation of breathing, even if the breathing stops for less than 10 second, if it repeats in a cycle more than ten times an hour, then an analeptic drug like Provigil or Armodafinil (Nuvigil) may well be needed.

Episodes of apnea are very rare during hours of wakefulness as our muscles are ‘in tone’ to keep the airway open.

However, during sleep our muscle tone relaxes – creating the problem.

To wake you up the brain usually instigates a loud snore or ‘snort’, stiffening the muscles in the respiratory system, to get you breathing again.

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Recognizing Obstructive Sleep Apnea

There are some symptoms for you to watch out for in terms of being able to tell yourself if you have obstructive sleep apnea.

However, if you sleep with someone else or have other people in nearby bedrooms – then listen out for comments from them about you occasionally/suddenly snoring or snorting very loudly when you’re asleep.

Sleep apnea sufferers can often also exhibit the signs of having an excessive desire to sleep during the day, often accompanied by symptoms of restlessness and irritability.

In extreme cases the instances of feeling excessively sleepy during the day can be associated with another sleeping disorder, narcolepsy, when you could literally fall asleep while driving, working or just talking to someone else.

Other symptoms of OSA include: morning headaches, forgetfulness, mood swings, behavioral changes, anxiety, depression and a loss of libido.

Of course having any, or indeed all, of these symptoms does not necessarily mean that you have OSA or should be taking Provigil to treat it.

However, you would be well recommended to visit your doctor and seek an expert medical diagnosis.

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The Occurrence of Obstructive Sleep Apnea

In varying degrees, bearing in mind that could mean merely very loud snoring, obstructive sleep apnea affects up to 4% of the male and 2% or the female population.

It is mainly associated within the age profile of 30 to 60 year olds, and generally its incidence rises with age.

As previously commented OSA occurs to varying degrees and some sufferers may not even be aware that they have OSA or could benefit from a treatment such as Provigil.

While quitting smoking and drinking no more than moderate amounts of alcohol are recommended to promote general good health, smokers and heavy drinkers should consider their lifestyle if diagnosed with OSA.

Being obese, indeed even just being overweight, can lead to and exasperate OSA, and so regular exercise and a healthy diet are also needed to combat this illness.

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Central Sleep Apnea

There is another sleeping disorder related to OSA worth mentioning here.

Central sleep apnea, CSA, is a much more serious condition than OSA.

In CSA the brain itself forgets to send the ‘wake up’ signal to start you breathing again; requiring continuous positive airway pressure (CPAP) treatment, to keep the airways open and working as well an analeptic drug such as Provigil.

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Modafinil /mo·daf·i·nil/ (mo-daf´ĭ-nil″) a central nervous system stimulant used in the treatment of narcolepsy.

Brand Names: Alertec (CA), Provigil

Pharmacologic class: Nonamphetamine CNS stimulant

Pharmacology: Wakefulness-promoting agent; however, precise mechanism(s) unknown.

Mechanism of Action: Increases the release of monoamines, increases histamine in the hypothalamus (source).

Thought to stimulate CNS by decreasing the release of gamma-aminobutyric acid (a CNS depressant), thereby increasing mental alertness.

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Modafinil

Pronunciation: (moe-DAF-i-nill)Class: Analeptic

Trade Names: 

Provigil - Tablets 100 mg- Tablets 200 mg

Alertec (Canada)

Absorption:

T max is 2 to 4 h. Food delays T max approximately 1 h.

Distribution:

Apparent Vd is 0.9 L/kg and protein binding is approximately 60%.

Metabolism:

Primary site is hepatic via hydrolytic deamination, S-oxidation, aromatic ring hydroxylation, and glucuronide conjugation. Major inactive metabolites are modafinil acid and modafinil sulfone. Modafinil induces it own metabolism via CYP-450 3A4 after chronic administration.

Elimination:

Approximately 80% (urine) and 1% (feces) are excreted in 11 days. The half-life is approximately 15 h.

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Modafinil is a memory-improving and mood-brightening psycho-stimulant.

Modafinil enhances wakefulness and vigilance by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.

It is used to treat excessive sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) or shift work sleep disorder (sleepiness during scheduled waking hours.

SWSD also encompasses the problems of difficulty falling asleep or staying asleep during scheduled sleeping hours in people who work at night or on rotating shifts).

Modafinil is in a class of medications called wakefulness promoting agents and is not an amphetamine.

It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.

This drug has a pharmacological profile that is notably different from amphetamines and methylphenidate (Ritalin).

Current research suggests Modafinil is a safe, effective and well-tolerated agent much like its older and better-tested analogue Adrafinil.

Some benefits of Modafinil is that it is long-acting and doesn’t tend to cause peripheral sympathetic stimulation like insomnia.

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The hypothalamus gland has a very important job — to connect the nervous system with the endocrine system.

He’s a real smooth operator and releases the hormone oxytocin, which plays a role in what you feel when you’re in love.

He works from deep inside your brain to make hormones that make other glands make hormones.

He even controls the so-called “master gland,” the pituitary gland.

The hypothalamus also has a hand in regulating body temperature, hunger, thirst, fatigue, and anger.

He’s kind of a big deal.

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Hypothalamus

Modafinil is an analeptic drug (a central nervous system stimulant medication) or eurogenic that regulates (or increases) certain chemicals in the hypothalmus of the brain, the area that controls wakefulness.

The exact mechanism of action of Modafinil is unclear, although numerous studies have shown it to increase the levels of various chemicals in the brain called monoamines.

Only a few specific areas of the brain are affected by Modafinil causing an increase in certain chemical production, they are:

  • Dopamine – in the striatum and nucleus accumbens
  • Noradrenaline – in the hypothalamus and ventrolateral preoptic nucleus
  • Serotonin – in the amygdala and frontal cortex

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Patricia Prattis Jennings, 63, first took Provigil during a 2003 trip to Europe.

Her doctor thought the drug — meant to help users suffering from a lack of sleep stay awake without jittery side effects — might counteract the jet lag that had plagued her throughout four globe-hopping decades as a pianist with the Pittsburgh Symphony Orchestra.

Her first morning in Switzerland, she popped half a pill.

Her usual fatigue disappeared almost instantly.

“I felt great all day and for a number of days after that,” she says.

The drug worked so well that she gave her husband some when he complained of feeling groggy.

 

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Matt Parsons couldn’t get through the day without drifting into an exhausted stupor.

Barely 30, the Midlothian, Virginia, office manager always woke up feeling like he hadn’t slept at all.

He started calling in sick to work. When he did show up, he didn’t accomplish much.

Eventually, he was diagnosed with a disorder that caused his limbs to jerk uncontrollably, disrupting his sleep.

Anti-seizure medicine was ruled out because of the side effects.

Instead, his doctor prescribed Provigil.

An hour after taking his first pill, he remembered that his living room needed painting: “I looked over at the paint cans,” he says, “got up, did all the prep, and painted the wall that evening.”

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A California lawyer had no medical reason to take the drug, but he did have a common complaint:

“I work 10 to 14 hours a day, so I would have no personal life if I didn’t sacrifice some sleep,”

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He now takes Provigil four times a day.

“At the right dosage,” he reported online, “this wonder drug is really great.”

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These (energy drinks) are what kept me going through the day when I was a student back in ’04, that and a steady diet of those little ephedra pills when they were still legal.

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I was reading an article about Provigil in the Readers Digest and it claimed that one 200mg pill would keep you alert for about 15 hours.

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That was exactly what I needed so after about two weeks of looking online (this is in 2004), I finally found a place that sold Modafinil (which is Provigil) for a reasonable price.

That was The Pharmacy Express or Freedom Pharmacy back then and they only sold 100mg pills (which were fine at the time).

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Modafinil doesn’t make me jittery or tweeky like the ephedra used to do and when it’s time to go to sleep, I can go to sleep.

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Eventually, he was diagnosed with a disorder that caused his limbs to jerk uncontrollably, disrupting his sleep. Anti-seizure medicine was ruled out because of the side effects. Instead, his doctor prescribed Provigil. An hour after taking his first pill, he remembered that his living room needed painting: “I looked over at the paint cans,” he says, “got up, did all the prep, and painted the wall that evening.”

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Sure, it’s easy to buy Provigil online, but what is Provigil anyway?

Why Buy Provigil?

Provigil, also commonly known as *Modafinil, was designed as an analeptic drug to treat people with narcolepsy, obstructive sleep apnea and shift work sleep disorder.

In short, all of those sleeping disorders mean that sufferers of them either cannot control where and when they will fall asleep and/or will spend abnormally long periods of time asleep in any one day.

Or, if you prefer, they need something to help them stay awake.

(I buy Provigil online to help me stay awake.)

Before the arrival of Provigil , as is outlined above, there were a variety of other drugs available to do this, most notably amphetamines, but all of them to some extent or other have adverse effects outweighing their benefit.

Even taking caffeine in very high amounts can be medically dangerous for some people!

Provigil works the same as other stimulants by releasing monoamines but, rather than just stimulating, it also raises the levels of hypothalamic histamines making it a novel wake promoting drug rather than a stimulant per se.

It is estimated that 90% of the Provigil use in the United States is “off-label”.

Provigil is great for excessive daytime sleepiness.

*Provigil is also known as Modalert, Modapro, Alertec, Modiadol and many other generic brand names.

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Provigil is being prescribed by many physicians to millions of people for “off-label” or “lifestyle” uses, including:

  • Age-related memory decline
  • Attention deficit disorder
  • Depression
  • Fatigue caused by high-pressure jobs requiring long hours
  • Fatigue caused by chemotherapy treatment for cancer patients
  • Fatigue experienced by persons suffering from diseases such as multiple sclerosis
  • Fatigue experienced by people who need to be awake and alert for extended amounts of times such as soldiers, truckers or students cramming for finals
  • Jet lag
  • Memory problems associated with Alzheimer’s disease
  • Post-anesthesia grogginess
  • Sleepiness caused by other prescription medications
  • Treatment for cocaine addiction

Currently, many clinical trials are taking place to assess the effectiveness in using Provigil to treat other conditions than EDS associated with narcolepsy, OSAHS and SWSD.

Provigil, Alertness and Mental Faculty Boosting

Provigil has for some years been used by various groups of people as an aide to keeping themselves alert and to boost their mental faculties, when they might otherwise begin to flag due to tiredness.

Provigil is a prescription drug designed to treat a range of sleeping disorders, particularly narcolepsy and obstructive sleep apnea.

So, the question naturally arises, why should people be using Provigil for other then the purposes for which it was designed?

A quick bit of sleep history.

Falling Asleep Without Provigil

Many people buy Provigil online just to keep up with the demands of their work schedule.

It’s a simple fact that these days our opportunities for getting the right amount of sleep that we might naturally need, are few and far between for the vast majority of the population.

Not getting enough natural sleep is a problem that has been developing over a few hundred years now; it is not only a ‘modern’ problem arising from our ‘modern’ lifestyles that leads some people to use drugs such as Provigil.

Ever since industrial scale manufacturing techniques were pioneered in the mid 18th century, ‘the man’ has wanted us to work more and more hours to keep his machines working and the profits rolling in.

Add to this the improvements in indoor lighting, initially gas lighting around the 1820s and then the wide-scale adoption of electric lighting some 100 years later, and working into, if not through, the night became quite common.

This in itself disrupted our circadian rhythms, the natural cycle of sleep and wakefulness we have according to whether it is dark or light, having to work when our bodies told us it was time to sleep and vice-versa.

Of course in those long distant pre-Provigil days taking other stimulants wasn’t unheard of be it workers taking in caffeine from tea and coffee or even the more affluent using cocaine.

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Modern Issues of Alertness and Boosting Mental Faculties

Provigil can boost mental faculties.

Today of course it is not the case that most of us have to work in industrial manufacturing or indeed have to work in jobs where we are required to work into, let alone through, the night.

However, increasing numbers of us are still unable to satisfy our natural circadian rhythm and to truly perform at 100% efficiency throughout the day could benefit from Provigil.

Whilst for some people they could undoubtedly do things themselves to help restore their state of natural sleep patterns, for many other people it is not a realistic option.

Although increasing numbers of us might not work in industrial manufacturing we are in jobs requiring more than a simple 9 to 5 mentality or work pattern.

We increasingly find ourselves asked to be in the office earlier to take a trans-Pacific conference or work late for a trans-Atlantic one, whilst always still being there during our core hours of work.

On getting home you’re technically still in the office working on your laptop etc; the day, or rather working hours, never seem to end.

When you do finally collapse into bed around midnight and do finally get to sleep, it doesn’t seem 5 minutes until the automated lighting system wants to wake you up before its daylight.

Provigil : A Possible Solution

OK, so the problem is that we can’t get the natural sleep we should have and in not getting the correct amount of rest we not only become tired but subsequently our mental faculties, abilities if you will, become impaired making us less efficient.

Throughout this article we’ve mentioned a drug called Provigil, but so far have only said it was designed to treat specific sleeping disorders; so why mention it as a possible help in maintaining the alertness of people who are not ill, or, indeed, of it being able to boost mental faculties.

The reason for this is quite simply that clinical studies in the USA, the UK and France have all shown Provigil to be capable of helping people to remain alert and boost their mental faculties.

Even better, the studies have shown Provigil to be a benign and non-addictive drug and not to give a ‘high’ or the symptoms associated with more dangerous stimulant drugs, like amphetamines or cocaine, that can help people to ‘stay awake’.

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